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Cape Girardeau Hotel Accommodation

October 2026
November 2026

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This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Where to stay in Cape Girardeau?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on quality, location and traveller experience. Last updated on 24 September 2026.
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
RM407
RM460 total
includes taxes & fees
28 Sept - 29 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

2. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
RM412
RM465 total
includes taxes & fees
1 Oct - 2 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

3. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
RM293
RM331 total
includes taxes & fees
28 Sept - 29 Sept
Pear Tree Inn Cape Girardeau West
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

4. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
RM412
RM468 total
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

5. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
RM367
RM414 total
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

6. The Riverview

The Riverview
Cape Girardeau
RM466
RM525 total
includes taxes & fees
28 Sept - 29 Sept
The Riverview
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A lobby with seating areas, a reception desk, and a bar.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

7. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
RM529
RM599 total
includes taxes & fees
4 Oct - 5 Oct
Courtyard by Marriott Cape Girardeau Downtown
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

8. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
RM431
RM486 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

9. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
RM346
RM413 total
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

10. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
RM244
RM276 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Cape Girardeau North
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.
A reception area with a counter, a flat-screen TV, and a window with blinds.

11. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
RM242
RM269 total
includes taxes & fees
27 Sept - 28 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel lobby with a reception desk, seating area, and a large window.
A hotel room with a desk, chair, television, and a lamp.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

12. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
RM289
RM320 total
includes taxes & fees
2 Oct - 3 Oct
Quality Inn Cairo I-57
A building with a fountain and flower beds in front.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

13. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
RM271
RM301 total
includes taxes & fees
26 Sept - 27 Sept
The Riverstone Hotel Charleston-Sikeston
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

14. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
RM343
RM371 total
includes taxes & fees
1 Oct - 2 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
An indoor swimming pool with clear water, marked lanes, and a lifeguard warning sign.
A hotel room with a treadmill, exercise bike, and dumbbells.
A dining area with wooden flooring, red upholstered chairs, and a mural of a pyramid.
A modern living room with two sofas, a coffee table, and a TV.

15. Hotel 7 Inn Anna

Hotel 7 Inn Anna
Anna
Hotel 7 Inn Anna
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

16. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
RM308
RM334 total
includes taxes & fees
22 Oct - 23 Oct
Comfort Suites Jackson-Cape Girardeau
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A bathroom with a sink, mirror, towel rack, shower, and toilet.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

17. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
RM314
RM348 total
includes taxes & fees
25 Sept - 26 Sept
Eagle Inn Charleston
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Check out pet-friendly hotels in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
RM407
RM460 total
includes taxes & fees
28 Sept - 29 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
RM293
RM331 total
includes taxes & fees
28 Sept - 29 Sept
Pear Tree Inn Cape Girardeau West
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
RM431
RM486 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
RM367
RM414 total
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A modern retail area with a display of local items and snacks.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
RM364
RM415 total
includes taxes & fees
11 Oct - 12 Oct
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
RM346
RM413 total
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
RM306
RM357 total
includes taxes & fees
25 Sept - 26 Sept
Town House Inn Cape Giradreau
View all properties

You may also like hotels with pools in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
RM407
RM460 total
includes taxes & fees
28 Sept - 29 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
RM412
RM468 total
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
RM367
RM414 total
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
RM431
RM486 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Cape Girardeau I 55 East
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
RM412
RM465 total
includes taxes & fees
1 Oct - 2 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern retail area with a display of local items and snacks.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
RM364
RM415 total
includes taxes & fees
11 Oct - 12 Oct
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
RM346
RM413 total
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
RM244
RM276 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Cape Girardeau North
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Go beyond your typical stay in Cape Girardeau

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Pet friendly
Pet friendly
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Pool
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Hot tub
Hot tub
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Spa
Spa
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Family friendly
Family friendly
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Cottage
Cottage
Our prices for hotels in Cape Girardeau are cheapest in January

Price trends for hotels in Cape Girardeau

Pricing is based on two traveller single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
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Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay?
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Hunter Valley Winery

7.4/10 (48 reviews)
Travellers might want a tour of Hunter Valley Winery, just one of the places to visit, located 9.3 mi (14.9 km) from central Cape Girardeau.
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Riverfront Park

8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
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Show Me Center

8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau? If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
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Cape Rock Park

8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
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Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Centre or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic city centre invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

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A nighttime view of a bridge with its cables illuminated against a starry sky.

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