Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on comfort, location and traveller experience. Last updated on .
Cape Girardeau Hotel Accommodation
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Tonight
13 Aug - 14 AugTomorrow
14 Aug - 15 AugThis weekend
14 Aug - 16 AugNext weekend
21 Aug - 23 AugTop 5 hotels in Cape Girardeau at a glance
- Drury Plaza Hotel Cape Girardeau Conference Center — 3-star hotel in Cape Girardeau. Guest rating: 9.6/10 — Exceptional.
- Fairfield Inn & Suites by Marriott Cape Girardeau — 3-star hotel in Cape Girardeau. Guest rating: 9.4/10 — Exceptional.
- Pear Tree Inn Cape Girardeau West — 2.5-star hotel in Cape Girardeau. Guest rating: 9.0/10 — Wonderful.
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG — 2.5-star hotel in Cape Girardeau. Guest rating: 9.4/10 — Exceptional.
- Drury Inn & Suites Cape Girardeau — 3-star hotel in Cape Girardeau. Guest rating: 9.4/10 — Exceptional.
Where to stay in Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
RM409
RM461 total
includes taxes & fees
23 Aug - 24 Aug
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
RM346
RM390 total
includes taxes & fees
24 Aug - 25 Aug
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
RM294
RM332 total
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
RM421
RM475 total
includes taxes & fees
13 Sept - 14 Sept
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
RM368
RM415 total
includes taxes & fees
21 Aug - 22 Aug
The Riverview
The RiverviewCape Girardeau
RM467
RM527 total
includes taxes & fees
16 Aug - 17 Aug
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
RM511
RM579 total
includes taxes & fees
22 Aug - 23 Aug
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
RM432
RM488 total
includes taxes & fees
20 Aug - 21 Aug
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHGCape Girardeau
RM335
RM400 total
includes taxes & fees
16 Aug - 17 Aug
Quality Inn Cape Girardeau North
Quality Inn Cape Girardeau NorthCape Girardeau
RM252
RM285 total
includes taxes & fees
6 Sept - 7 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
RM243
RM270 total
includes taxes & fees
16 Aug - 17 Aug
Quality Inn Cairo I-57
Quality Inn Cairo I-57Cairo
RM294
RM326 total
includes taxes & fees
20 Aug - 21 Aug
The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-SikestonCharleston
RM272
RM301 total
includes taxes & fees
7 Sept - 8 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
RM379
RM410 total
includes taxes & fees
16 Aug - 17 Aug
Hotel 7 Inn Anna
Hotel 7 Inn AnnaAnna
RM311
RM360 total
includes taxes & fees
16 Aug - 17 Aug
Comfort Suites Jackson-Cape Girardeau
Comfort Suites Jackson-Cape GirardeauJackson
RM345
RM374 total
includes taxes & fees
16 Aug - 17 Aug
Eagle Inn Charleston
Eagle Inn CharlestonCharleston
RM283
RM314 total
includes taxes & fees
14 Aug - 15 Aug
Check out hotels with a pool in Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
RM409
RM461 total
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
RM421
RM475 total
includes taxes & fees
13 Sept - 14 Sept
RM368
RM415 total
includes taxes & fees
21 Aug - 22 Aug
RM432
RM488 total
includes taxes & fees
20 Aug - 21 Aug
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
RM346
RM390 total
includes taxes & fees
24 Aug - 25 Aug
RM365
RM416 total
includes taxes & fees
23 Aug - 24 Aug
RM335
RM400 total
includes taxes & fees
16 Aug - 17 Aug
RM252
RM285 total
includes taxes & fees
6 Sept - 7 Sept
You can also stay at pet-friendly hotels in Cape Girardeau
RM368
RM415 total
includes taxes & fees
21 Aug - 22 Aug
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
RM409
RM461 total
includes taxes & fees
23 Aug - 24 Aug
RM294
RM332 total
includes taxes & fees
23 Aug - 24 Aug
RM432
RM488 total
includes taxes & fees
20 Aug - 21 Aug
RM335
RM400 total
includes taxes & fees
16 Aug - 17 Aug
RM365
RM416 total
includes taxes & fees
23 Aug - 24 Aug
RM286
RM334 total
includes taxes & fees
5 Sept - 6 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Cape Girardeau
Pet friendly
Family friendly
Our prices for hotels in Cape Girardeau are cheapest in January
Our prices for hotels in Cape Girardeau are cheapest in January
Price trends for hotels in Cape Girardeau
Pricing is based on two traveller single night rates
Top landmarks in Cape Girardeau
Southeast Missouri State University
8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
Riverfront Bridge Park
8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay?
Riverfront Park
8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
Cape Splash Family Aquatic Center
8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau? If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
Hunter Valley Winery
7.4/10 (48 reviews)
Travellers might want a tour of Hunter Valley Winery, just one of the places to visit, located 9.3 mi (14.9 km) from central Cape Girardeau.
Cape Rock Park
8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
Show Me Center
8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
Learn more about Cape Girardeau
Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Centre or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic city centre invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.
See all hotels in Cape Girardeau
Check out reviews of Cape Girardeau hotels guests love
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
8/10 Good
"The room was clean and staff was friendly. The breakfast was alright. The hot stuff didn't seem very fresh for only being 30 minutes into breakfast."
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"20/10 stars! Was highly impressed with EVERY single aspect of our stay here."
The Riverview
10/10 Excellent
"Very well kept"
Drury Inn & Suites Cape Girardeau
10/10 Excellent
"Clean rooms and delicious buffet"
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Very friendly professional and helpful staff. Clean comfortable room. Close parking. Close to lots of shopping"
Tru By Hilton Cape Girardeau
10/10 Excellent
"Clean"
Candlewood Suites Cape Girardeau by IHG
8/10 Good
"Very nice place"
Town House Inn Cape Giradreau
10/10 Excellent
"Its always a peaceful stay for me 💗"
Hampton Inn Cape Girardeau I 55 East
10/10 Excellent
"Good Job!"
Frequently asked questions
Keep exploring
- Pinhook Hotels
- Hotels with Parking in Jackson
- Hotels near Fort D Historic Site
- Cheap Hotels in Sikeston
- Hotels near Southeast Missouri State University
- Hotels near Lake Wappapello
- Ozora Hotels
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Southeast Missouri Hospital
- Morehouse Hotels
- Hotels near City of Miner Convention Center
- Dexter Hotels
- Ste Genevieve Hotels
- Wyatt Hotels
- Hotels with a Pool in Sikeston
- Benton Hotels
- Gordonville Hotels
- Hotels near Riverfront Bridge Park
- Frohna Hotels
- Scott County Hotels
- Hotels near eDen Spa & Salon
- Marquand Hotels
- Matthews Hotels
- New Madrid Hotels
- Fredericktown Hotels
- Cheap Hotels in Cape Girardeau
- Gay friendly Hotels in Cape Girardeau
- Hotels near Litz Park
- Hotels near Show Me Center
- Hotels near Silver Mine Recreation Area
- Kelso Hotels
- Perryville Hotels
- Hotels near Isle Casino Cape Girardeau
- Miner Hotels
- Greenville Hotels