Panacea Hotel Accommodation

October 2026
November 2026

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This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Where to stay in Panacea?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Panacea on Hotels.com. These Panacea hotels consistently deliver on quality, location and traveller experience. Last updated on 25 September 2026.

1. The Panacea Motel

The Panacea Motel
Panacea
RM486
RM542 total
includes taxes & fees
8 Oct - 9 Oct
The Panacea Motel

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
RM454
RM507 total
includes taxes & fees
11 Oct - 12 Oct
Best Western Wakulla Inn & Suites

3. Wildwood Inn

Wildwood Inn
Crawfordville
RM472
RM543 total
includes taxes & fees
11 Oct - 12 Oct
Wildwood Inn

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
RM365
RM407 total
includes taxes & fees
27 Sept - 28 Sept
The Lodge at Wakulla Springs

5. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
RM517
RM725 total
includes taxes & fees
27 Sept - 28 Sept
St James Bay Golf & Pickleball Resort

6. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
RM408
RM450 total
includes taxes & fees
8 Oct - 9 Oct
The Old Carrabelle Hotel

7. Franklin Inn

Franklin Inn
Carrabelle
RM384
RM424 total
includes taxes & fees
27 Sept - 28 Sept
Franklin Inn

8. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
RM563
RM622 total
includes taxes & fees
1 Oct - 2 Oct
The Moorings Hotel and Marina
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The Panacea Motel

The Panacea Motel
Panacea
We have 2 left at
RM564
per night
RM1,257 total
includes taxes & fees
The Panacea Motel

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
Panacea
We have 1 left at
RM642
per night
RM2,517 total
includes taxes & fees
2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!

Waterfront Home: Spectacular On-site Fishing!

Waterfront Home: Spectacular On-site Fishing!
Panacea
We have 1 left at
RM891
per night
RM3,296 total
includes taxes & fees
Waterfront Home: Spectacular On-site Fishing!

Waterfront Panacea Vacation Rental w/ Dock!

Waterfront Panacea Vacation Rental w/ Dock!
Panacea
We have 1 left at
RM989
per night
RM2,874 total
includes taxes & fees
Waterfront Panacea Vacation Rental w/ Dock!

Nature Lover's Paradise: Hike, Bike & Fish!

Nature Lover's Paradise: Hike, Bike & Fish!
Panacea
We have 1 left at
RM789
per night
RM3,400 total
includes taxes & fees
Nature Lover's Paradise: Hike, Bike & Fish!

Go beyond your typical stay in Panacea

pet-friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
spa image
Spa
Spa
Cottage image
Cottage
Cottage
Family-friendly image
Family friendly
Family friendly
Our prices for hotels in Panacea are cheapest in February

Price trends for hotels in Panacea

Pricing is based on two traveller single night rates
View properties in September

September

High 30°C / low 23°C. Sunny most days.
30°
23°
27°
18°
22°
13°
19°
11°
17°
8°
19°
10°
22°
13°
25°
16°
29°
20°
31°
23°
32°
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32°
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Monthly weather averages (˚C)

Top landmarks in Panacea

Alligator Point Beach

8.8/10 (10 reviews)
When the beach is calling your name, you might want to head down to Alligator Point Beach, located 4.5 mi (7.2 km) from central Alligator Point. Enjoy the sunset by the shore at Wilson Beach.
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Bald Point State Park

8.6/10 (20 reviews)
Bald Point State Park is 1.7 mi (2.7 km) from central Alligator Point, why not stop by during your stay?
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Mashes Sand Beach

8.8/10 (3 reviews)
If being by the water is a major draw, Mashes Sand Beach is a spot you might want to check out, located 5.1 mi (8.2 km) from central Panacea. If you want to continue walking by the waves, head to Shell Point Beach, Wilson Beach and Alligator Point Beach.
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Wilson Beach

Whether you want to collect beach glass or watch the sunset, Wilson Beach is a spot you might want to check out, located 7.4 mi (11.9 km) from central Panacea. Enjoy the sunset by the shore at Alligator Point Beach.
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beach near Summer Camp Beach

Whether you want to collect beach glass or watch the sunset, beach near Summer Camp Beach is a spot you might want to check out, located 10.3 mi (16.6 km) from central Panacea. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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Public Beach Access

Public Beach Access is 2.3 mi (3.7 km) from central Alligator Point, why not stop by during your stay? Want to stretch your legs a little more? Head to Alligator Harbor Aquatic Preserve, located nearby.
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beach near Alligator Point

When the beach is calling your name, you might want to head down to beach near Alligator Point, located 2.7 mi (4.4 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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beach near Alligator Point Marina

When the beach is calling your name, you might want to head down to beach near Alligator Point Marina, located 3 mi (4.8 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants and sights like Bald Point State Park and Wilson Beach—all within a secluded setting.

See all hotels in Panacea
A coastal resort with beachfront villas and a clear blue sky.

Frequently Asked Questions

How much does a hotel room cost in Panacea?

You can find top hotels in Panacea from RM 364 with options to suit your budget and needs. If you're looking for an affordable hotel in Panacea that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Panacea hotels?

Discover great deals on Panacea hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Panacea hotels.

Can I book Panacea hotels with free cancellation?

To book a refundable Panacea hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Find out more about Panacea

Panacea: Embrace the Coastal Serenity and Untamed Wilderness

Discover the serene charm of Panacea, Florida, where pristine beaches meet lush, unspoilt nature. This hidden gem offers a tranquil retreat with its inviting coastal landscapes and captivating natural springs. Ideal for those seeking a peaceful escape, Panacea promises refreshing seaside walks and a chance to reconnect with nature in an idyllic setting. Perfect for nature enthusiasts and beach lovers alike, Panacea is your go-to destination for a rejuvenating break in an unhurried, picturesque environment.

Discover great hotels near Panacea

Panacea offers a range of accommodation options from cosy motels to stylish hotels, with room rates to suit different budgets. Many properties feature free cancellation and a friendly, relaxed atmosphere, making them ideal for a laid-back stay in this Floridian coastal town. Here are some of the best hotels near Panacea that our travelers love:

  1. Best Western Wakulla Inn & Suitesopens in new window: This 3-star hotel boasts an impressive guest rating and is an ideal choice for leisure travellers seeking a blend of adventure and comfort. Guests enjoy a variety of engaging activities such as boat tours, cycling, kayaking, hiking and snorkelling, all within easy reach. The hotel stands out with its curated experiences and smooth express check-in, ensuring a seamless arrival. Frequent travellers will appreciate the stylish ambience, high-end amenities and thoughtful design that create a truly unique escape.
  2. Wildwood Innopens in new window: With a solid 3.0-star rating and an excellent guest rating, this hotel caters exceptionally well to leisure travellers who revel in dynamic and energising experiences. Guests have enjoyed the convenience of efficient check-in and the availability of exciting outdoor activities including kayaking, boat tours, sailing, mountain biking and hiking. The property is distinguished by its modern architectural design, curated experiences and high-quality amenities that ensure a smooth, memorable stay.
  3. St James Bay Golf & Pickleball Resortopens in new window: This 3.5-star hotel is a top choice for leisure travellers seeking both adventure and relaxation. With a high guest rating and a focus on distinctive experiences, the hotel offers exclusive golf-themed activities alongside engaging adventures such as boat tours, sailing, hunting, waterskiing and windsurfing. The venue is celebrated for its boutique setting, stylish design and seamless express check-in, creating an inviting atmosphere for those in search of a memorable, high-quality escape.

Where to stay in and around Panacea

In Alligator Point, Crawfordville, Saint Teresa, each offers unique appeal: Alligator Point provides scenic coastal charm; Crawfordville is ideal for nature lovers with hiking, boating and dining in a family-friendly setting; Saint Teresa offers a tranquil escape. For first-time visitors to Panacea, Crawfordville is best suited for its diverse attractions.

  1. Alligator Pointopens in new window: Alligator Point is a charming coastal destination perfect for those looking to unwind by the beach. Known for its stunning sunsets and tranquil atmosphere, this spot is ideal for nature lovers and families alike. You can enjoy activities like boating and fishing, or simply relax on the sandy shores. The area is also great for wildlife enthusiasts, with opportunities to spot various birds and sea life. For accommodation, you’ll find cosy beach houses and charming inns that provide a welcoming environment, ensuring a delightful stay while you explore the natural beauty surrounding you.
  2. Crawfordvilleopens in new window: Nestled inland, Crawfordville offers a rich blend of outdoor activities and family-friendly attractions. With its beautiful forests and abundant wildlife, this area is a haven for hiking and nature walks. Visitors can enjoy serene trails that wind through scenic landscapes, making it a perfect choice for those who appreciate the great outdoors. The friendly community vibe adds to the charm, making it a welcoming place for all travellers. You’ll find a range of comfortable lodgings, from quaint bed and breakfasts to modern hotels, ensuring a pleasant stay while you discover the local charm.
  3. Saint Teresaopens in new window: Saint Teresa is a hidden gem along Florida's coastline, ideal for visitors seeking a peaceful retreat. This quaint area is noted for its stunning beaches and calm waters, perfect for a relaxing day by the sea. With a family-friendly atmosphere, it's a great spot for beach picnics and leisurely strolls along the shore. The surrounding nature provides opportunities for boating and wildlife observation, making it an excellent choice for those who enjoy outdoor activities. Lodging options here include charming beachfront cottages and cozy inns, providing a relaxing escape in a picturesque setting.

Things to do in Panacea

Panacea beckons travellers with its pristine beaches, lush forests, and rolling hills. Enjoy boating, sea diving, and fishing, or simply savour breathtaking sunsets. Discover local wildlife and playful dolphins, and relax in comfortable Panacea hotels for an unforgettable seaside escape.

  • Wakulla Springs State Parkopens in new window – Explore Wakulla Springs State Park, a national state park where you can enjoy the natural beauty and clear waters along the beach. Take a gentle stroll around the park, and appreciate the pristine environment and abundant wildlife that make this location a refreshing escape into nature.
  • Shell Point Beachopens in new window – Visit Shell Point Beach, a beach destination that offers a sunny retreat along the coastline. Enjoy a relaxed day by the water, with the gentle sound of waves and the sandy shores perfect for a family outing or a quiet moment of reflection in the open air.
  • Ochlockonee River State Parkopens in new window – Discover Ochlockonee River State Park, a national state park that invites you to explore its riverside settings and lovely beach areas. The park provides opportunities for leisurely walks and moments of tranquillity by the water, making it an ideal spot for nature enthusiasts.
  • Alligator Point Beachopens in new window – Head to Alligator Point Beach, a beach known for its serene atmosphere and scenic views. The location offers a pleasant setting for a day out, where you can enjoy the refreshing sea breeze and the simplicity of the coastal landscape.
  • Bald Point State Parkopens in new window – Experience Bald Point State Park, a national state park that combines the charm of a beach with the beauty of natural surroundings. With its expansive views and diverse terrain, it is a wonderful destination for those looking to enjoy both the sea and the great outdoors.

4 tips for savvy savings when booking a hotel in Panacea

  1. Book for the cheapest times: The most affordable times to visit Panacea are January, July, and December, when hotel prices tend to be lower. For a budget-friendly experience, it's recommended to stay for at least 2 to 3 days to fully appreciate the area's historical landmarks, cultural sites, and stunning natural attractions. During your visit, you can indulge in relaxing beach days, enjoy dolphin watching, savour fresh seafood, and witness breathtaking sunsets, all while exploring the rich wildlife and serene nature spots. This makes for a great value-for-money getaway that won’t break the bank.
  2. Look for last-minute deals on Hotels.com: Panacea may discover excellent hotel deals by exploring the Dealsopens in new window section on Hotels.com, where discounted rates on hotels near your travel date are featured. If you're seeking a spontaneous getaway, the Last-Minute Deals section could provide opportunities for savings. By enabling notifications, you are more likely to see flash sales and special offers, while the Smart Shopping comparison tool available via the app helps travellers compare hotel prices and amenities effortlessly. Enjoy the search for the best deal on Panacea hotels with these features.
  3. Be flexible with dates: Prices may vary due to factors such as the hotel's location, star rating, and the time of year, so being flexible with your dates might help you save on your stay at Panacea hotel. For those seeking unique experiences, boutique hotels may offer a more personalised service and sometimes even more attractive value. When you book with Hotels.com, we will inform you if the price for your selected dates is above or below the average. Should the price appear higher, we might suggest more affordable dates to assist you in finding a better deal.
  4. Consider your location: Opting for accommodation nearer to major attractions or city centres may provide convenience, but it often comes with a steeper price tag. For more budget-friendly options, you might consider hotels in less central areas or neighbourhoods, striking a balance between cost and accessibility to the sights you wish to explore. Additionally, independent hotels located further out are usually more likely to be affordable and can offer a more authentic experience.

Best time to go to Panacea

Panacea experiences its lowest average temperature in January, at 53.6°F (12.0°C), while July to August are the hottest months, with an average temperature of 81.7°F (27.6°C). August tends to be the wettest month. The peak travel months to visit Panacea are April, June, and July, which see a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light to moderate rainfall. In contrast, October to December are ideal if you're looking for a calmer vacation, marked by light rainfall and mostly sunny conditions.

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