Seneca Hotel Accommodation

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Check prices for these dates

Tonight
6 Oct - 7 Oct
Tomorrow
7 Oct - 8 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on .

A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
RM490
RM539 total
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A reception area with a counter, chairs, and a patterned rug.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
RM489
RM537 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn & Suites Seneca-Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
RM432
RM475 total
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
RM382
RM420 total
includes taxes & fees
28 Oct - 29 Oct
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
RM431
RM536 total
includes taxes & fees
9 Oct - 10 Oct
Lakeside Lodge Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
RM309
RM364 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM339
RM373 total
includes taxes & fees
8 Oct - 9 Oct
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
RM380
RM598 total
includes taxes & fees
4 Nov - 5 Nov
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

9. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
RM854
RM948 total
includes taxes & fees
13 Oct - 14 Oct
The Shepherd Hotel Downtown Clemson
A golf course with a water body, trees, and a distant view of a bridge.
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
A modern building with a central entrance, surrounded by a well-maintained lawn and trees.
A golf course with a clubhouse, surrounded by dense trees and a large body of water.

10. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
RM609
RM676 total
includes taxes & fees
7 Oct - 8 Oct
Clemson University's James F. Martin Inn
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

11. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
RM658
RM730 total
includes taxes & fees
18 Oct - 19 Oct
The Abernathy of Clemson
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A conference room with a large round table, multiple chairs, and a projector.
A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.
A modern living room with a flat-screen TV, a desk with a chair, an orange sofa, and a framed tiger picture on the wall.

12. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
RM527
RM585 total
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Clemson by IHG
A modern kitchen area with a bar counter and seating.
A modern bar area with high stools and a poolside view.
A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.
A vending area with snacks and beverages, including chips and soda.

13. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
RM448
RM497 total
includes taxes & fees
12 Oct - 13 Oct
Hampton Inn Clemson-University Area
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.
A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
RM431
RM478 total
includes taxes & fees
8 Oct - 9 Oct
Best Western Plus Clemson Hotel & Conference Center
A hotel room with a bed, desk, chair, and a microwave.
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.
Room
A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.

15. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
RM437
RM486 total
includes taxes & fees
18 Oct - 19 Oct
Comfort Inn & Suites Clemson - University Area
A modern bar area with a menu board, bar stools, and a countertop with various items.
A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.
A modern dining area with a bar, bar stools, and a patterned rug.
A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.

16. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
RM511
RM567 total
includes taxes & fees
18 Oct - 19 Oct
Courtyard Marriott Clemson
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.
A brick building with a sign reading "The Inn at Patrick Square".

17. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
RM609
RM676 total
includes taxes & fees
7 Oct - 8 Oct
The Inn at Patrick Square
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A wall with a decorative design featuring a building, trees, and a sky with clouds.

18. Inn @ Clemson

Inn @ Clemson
Clemson
RM327
RM363 total
includes taxes & fees
7 Oct - 8 Oct
Inn @ Clemson
A kitchen with a coffee maker, microwave, and refrigerator.
A hotel room with a bed, a desk with a chair, a television, a small table, and a microwave.
A hotel room with a large bed, a bedside table, a nightstand, and a wall-mounted lamp.
A reception area with a check-in desk, a seating area with a bench, and a wall-mounted display of postcards.

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
RM312
RM348 total
includes taxes & fees
4 Nov - 5 Nov
Rodeway Inn & Suites Walhalla
A hotel lobby with a reception desk, seating area, and a view of the street outside.
A reception area with a desk, two chairs, a large water dispenser, and a painting on the wall.
A compact bathroom with a white sink, a mirror, a black refrigerator, and a towel rack with wooden hangers.
A hotel room with a bed, desk, chair, nightstand, lamp, and a view of the outside through curtains.

20. Econo Lodge Clemson - University Area

Econo Lodge Clemson - University Area
Clemson
RM364
RM411 total
includes taxes & fees
12 Oct - 13 Oct
Econo Lodge Clemson - University Area
View all properties

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A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
We have 6 left at
RM368
per night
RM431 total
includes taxes & fees
Quality Inn Seneca US-123
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A reception area with a counter, chairs, and a patterned rug.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
We have 7 left at
RM548
per night
RM602 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 5 left at
RM568
per night
RM625 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
RM486
per night
RM535 total
includes taxes & fees
Best Western Seneca-Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM364
per night
RM400 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
RM445
per night
RM553 total
includes taxes & fees
Lakeside Lodge Clemson
An outdoor patio area with a fire pit, seating, and string lights.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
We have 2 left at
RM568
per night
RM625 total
includes taxes & fees
Tru by Hilton Seneca Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
We have 5 left at
RM466
per night
RM692 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A reception area with a counter, chairs, and a patterned rug.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
RM548
per night
RM602 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
We have 8 left at
RM368
per night
RM431 total
includes taxes & fees
Quality Inn Seneca US-123
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 5 left at
RM568
per night
RM625 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
RM486
per night
RM535 total
includes taxes & fees
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
RM445
per night
RM553 total
includes taxes & fees
Lakeside Lodge Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM380
per night
RM418 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
We have 1 left at
RM568
per night
RM625 total
includes taxes & fees
Tru by Hilton Seneca Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
We have 1 left at
RM466
per night
RM692 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
We have 2 left at
RM438
per night
RM1,020 total
includes taxes & fees
Quality Inn Seneca US-123
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 1 left at
RM1,058
per night
RM2,329 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM488
per night
RM1,074 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
RM865
per night
RM1,903 total
includes taxes & fees
Best Western Seneca-Clemson
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A reception area with a counter, chairs, and a patterned rug.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
We have 1 left at
RM1,324
per night
RM2,913 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
We have 4 left at
RM1,263
per night
RM3,138 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A clear lake with a rocky shoreline and a tree branch overhanging the water.
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.
A grassy area with trees and a body of water.
A two-story building with a garage, a staircase, and a view of the water.

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
We have 1 left at
RM905
per night
RM2,937 total
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape
A covered deck with wooden beams, wicker furniture, and large windows overlooking a lake.
A covered outdoor deck with wooden beams, large windows, wicker furniture, and a swing.
A modern kitchen with a built-in stove, stainless steel appliances, and patterned flooring.
A single-story house with a covered porch, a driveway, and a view of the water.

Stunning Seneca Home w/ Lake Keowee Access!

Stunning Seneca Home w/ Lake Keowee Access!
Seneca
We have 1 left at
RM2,362
per night
RM6,407 total
includes taxes & fees
Stunning Seneca Home w/ Lake Keowee Access!
A wooden deck with a metal roof, overlooking a lake and houses.
A kitchen with a wooden table, white cabinets, a microwave, a coffee maker, and a sink.
A modern multi-story building with a wooden staircase leading up to a balcony, surrounded by trees.
A wooden bridge leading to a house with a view of a lake.

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
We have 1 left at
RM2,094
per night
RM5,680 total
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails
A covered patio with wooden chairs and a table, overlooking a fenced yard with a body of water and trees.
A modern kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a dishwasher.
A spacious living area with a sofa set, a glass coffee table, and a ceiling fan.
A house with a pathway leading to a dock, surrounded by trees and a body of water.

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
We have 1 left at
RM1,614
per night
RM4,376 total
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
RM431
RM536 total
includes taxes & fees
9 Oct - 10 Oct
Lakeside Lodge Clemson
An outdoor patio area with a fire pit, seating, and string lights.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
RM432
RM475 total
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
RM309
RM364 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM339
RM373 total
includes taxes & fees
8 Oct - 9 Oct
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
RM380
RM598 total
includes taxes & fees
4 Nov - 5 Nov
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
View all properties

You may also like hotels with pools in Seneca

A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
RM490
RM539 total
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A reception area with a counter, chairs, and a patterned rug.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
RM489
RM537 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn & Suites Seneca-Clemson Area
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
RM431
RM536 total
includes taxes & fees
9 Oct - 10 Oct
Lakeside Lodge Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
RM309
RM364 total
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
RM382
RM420 total
includes taxes & fees
28 Oct - 29 Oct
Best Western Seneca-Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
RM339
RM373 total
includes taxes & fees
8 Oct - 9 Oct
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in January
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in October
Typical weather for Seneca
October
High 23°C / low 12°C. Sunny most days.
View properties in October
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3°
17°
6°
22°
10°
26°
15°
31°
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Monthly weather averages (˚C)

Top neighbourhoods in Seneca

A lakeside scene with autumn foliage, a clear sky, and a sunset.
A large lake surrounded by dense forests.

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Toy Train Park

Toy Train Park is worth a pic or two when discovering Downtown.
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Highpointe Field

Highpointe Field is worth a visit, located 5.6 mi (8.9 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A sunset over a lake surrounded by dense forests and residential areas.

Check out reviews of Seneca hotels guests love

Quality Inn Seneca US-123

Quality Inn Seneca US-123

8/10 Good
"Second time here! Staff great! This time my room smelled of smoke as a non smoking room! Comforter was clean but from a smoking room and smelled despite it being clean!"
Gina 2-night trip
Posted 4 hours ago
Quality Inn Seneca US-123
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Great place to stay when visiting Clemson!"
Lloyd 1-night trip
Posted 3 days ago
Hampton Inn & Suites Seneca-Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"Stayed @ hotel for a football weekend. Hotel was awesome...one of the cleanest I've ever stayed in regardless of hotels' star ratings. The only reason I gave it 4 stars was two things....#1 The bed was a bit too hard for me. I'm used to softer mattresses, but these were a little too hard for me. #2....There was one staff person that was just not very friendly @ the front desk for part of my stay. She wasn't rude & she fulfilled my requests, but she just was not as outgoing as other team members & that stuck out to me. Would I stay at this hotel again? Absolutely...it's been many yrs since I've stayed in a BW...I tend to stay in the upper crust hotels, so I was very pleasantly surprised! Great job Best Western!!"
Susan 2-night trip
Posted 4 days ago
Best Western Seneca-Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Staff was great! Room was clean!"
Gretchen 2-night trip
Posted 8 days ago
Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"We were in town for parents weekend. Only reasonably priced accommodation. At first I was surprised at how remote the cabins were. But I understand it’s on purpose for people that want to disconnect and enjoy nature. We had no problem finding the place. It was clean. It was cozy. It was an adventure!"
Maria 2-night trip
Posted 12 days ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Frequently asked questions

How much does a hotel room cost in Seneca?
You can find top hotels in Seneca from RM348 with options to suit your budget and needs. If you're after an affordable hotel in Seneca that meets all of your requirements, set your filters and then sort the results by "Price: low to high".
How can I find deals and earn rewards at Seneca hotels?
Discover great deals on Seneca hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. And make sure to check out our last-minute deals on Seneca hotels.
Can I book Seneca hotels with free cancellation?
It's easy to book a refundable Seneca hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some of the best Seneca hotels with free parking?
If you're exploring by car, finding a great Seneca hotel with free parking is a win. Our travellers' favourites include:
Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 217 holiday homes. In addition, there are 24 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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